Centre d’expertise pour la recherche en immuno-transplantation et en oncologie

IGO Oncogreffe IHULe Labex IGO, avec le soutien de l’IHU et du DHU a le plaisir d’inviter le Dr Philippe Kastner (IGBMC, http://www.igbmc.fr/Kastner/, Strasbourg) le vendredi 20 mai à 11h00 (Salle Jean Monnet, 30 Bd Jean Monnet)
pour le séminaire “Role of the Ikaros transcription factor in plasmacytoid dendritic cell differentiation”

Summary of the team’s interest:
The overall aim of the team is to understand how specific transcriptional regulators shape complex developemental decisions, and how deregulation of these processes contributes to pathology, notably leukemia. We focus our work on the function of a family of transcriptional regulators, the Ikaros family of zinc finger proteins (Ikaros, Helios, Aiolos, Eos; encoded by the Ikzf1-4 genes), in the hematopoietic system. Importantly, Ikaros is a tumor suppressor in several types of leukemias, and notably B-cell acute lymphoblastic leukemia (B-ALL) where loss of Ikaros function is associated with poor prognosis (mostly via loss of a single allele). We have obtained results that highlight the key role of Ikaros in controlling several important aspects of B, T and dendritic cell differentiation, such as the control of Notch, IL-7 signaling or TGFb signaling, or the silencing of the stem cell gene expression program. These data provide novel fundamental insight into critical aspects of hematopoiesis, with possible implications for mechanisms of leukemogenesis. Interestingly, they paint a picture in which Ikaros seems to act to antagonize the function of important molecular pathways to regulate differentiation events and cellular responses.


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